Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits muramyl dipeptide binding activity. Involved in several processes, including positive regulation of cellular metabolic process; regulation of cytokine production; and response to bacterium. Predicted to localize to several cellular components, including anchored component of plasma membrane; basolateral plasma membrane; and phagocytic vesicle. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2).