Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vipas39. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2 (arthrogryposis, renal dysfunction, and cholestasis-2). Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Vipas39:
  • participates in the following biological processes:
    • endosome to lysosome transport
    • intracellular protein transport
  • is located in the following cellular components:
    • cytoplasm
    • early endosome
    • late endosome
    • recycling endosome

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Vipas39 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • protein transport
    • regulation of transcription, DNA-dependent
    • spermatogenesis
    • transcription, DNA-dependent
    • transport
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • endosome
• Annotations directly to molecular function for the gene Vipas39 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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