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Gene Ontology Classifications

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Myocd. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 22, 2011. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Cao D et al. (2005) Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol, 25:364-76. (PubMed:15601857)
  2. Creemers EE et al. (2006) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol Cell, 23:83-96. (PubMed:16818234)
  3. Du KL et al. (2003) Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol, 23:2425-37. (PubMed:12640126)
  4. Hayashi K et al. (2006) Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription. Mol Cell Biol, 26:9456-70. (PubMed:17030628)
  5. Hoofnagle MH et al. (2011) Myocardin is Differentially Required for the Development of Smooth Muscle Cells and Cardiomyocytes. Am J Physiol Heart Circ Physiol, null:null. (PubMed:21357509)
  6. Huang J et al. (2008) Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest, 118:515-25. (PubMed:18188448)
  7. Huang J et al. (2009) Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci U S A, 106:18734-9. (PubMed:19850880)
  8. Imamura M et al. (2010) Expression and functional activity of four myocardin isoforms. Gene, 464:1-10. (PubMed:20385216)
  9. Kuwahara K et al. (2005) Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol Cell Biol, 25:3173-81. (PubMed:15798203)
  10. Li S et al. (2003) The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A, 100:9366-70. (PubMed:12867591)
  11. Lockman K et al. (2007) The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression. Circ Res, 101:e115-23. (PubMed:17991879)
  12. Long X et al. (2007) Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc Natl Acad Sci U S A, 104:16570-5. (PubMed:17940050)
  13. Petit MM et al. (2008) Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin. Circ Res, 103:61-9. (PubMed:18511849)
  14. Qiu P et al. (2005) Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Circ Res, 97:983-91. (PubMed:16224064)
  15. Ueyama T et al. (2003) Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis. Mol Cell Biol, 23:9222-32. (PubMed:14645532)
  16. Wang D et al. (2001) Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell, 105:851-62. (PubMed:11439182)
  17. Zhou J et al. (2009) The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol, 29:921-8. (PubMed:19342595)
  18. Zhou J et al. (2008) Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding. J Biol Chem, 283:35383-92. (PubMed:18945672)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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