Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including positive regulation of protein ubiquitination; positive regulation of transforming growth factor beta receptor signaling pathway; and protein polyubiquitination. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including heart; nervous system; testis; and urinary system. Orthologous to human RNF111 (ring finger protein 111).