Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lias. (This text reflects annotations as of Wednesday, August 14, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 9, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lias
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3, 4]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lias
  • participates in the following biological processes:
    • inflammatory response ^[5]
    • neural tube closure ^[1]
    • response to lipopolysaccharide ^[5]
    • response to oxidative stress ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Lias
  • participates in the following biological processes:
    • lipoate biosynthetic process based on interactions with ^[3]
  • performs the following molecular functions:
    • lipoate synthase activity based on interactions with ^[3]

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Summary text based on GO annotations supported by structural data

• Lias encodes a protein or proteins that contain the following InterPro domains: Aldolase-type TIM barrel, Elongator protein 3/MiaB/NifB, Lipoyl synthase, Radical SAM, indicating that the gene product:
  • performs the following molecular functions:
    • 4 iron, 4 sulfur cluster binding
    • catalytic activity
    • iron-sulfur cluster binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lias indicates that it:
  • performs the following molecular functions:
    • 4 iron, 4 sulfur cluster binding
    • iron-sulfur cluster binding
    • metal ion binding
    • transferase activity

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References

1. Garcia-Garcia MJ et al. (2005) Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A, 102:5913-9. (PubMed:15755804)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Morikawa T et al. (2001) Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria. FEBS Lett, 498:16-21. (PubMed:11389890)
4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
5. Yi X et al. (2009) Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury. J Leukoc Biol, 85:146-53. (PubMed:18845616)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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