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Gene Ontology Classifications
hepcidin antimicrobial peptide

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GO curators for mouse genes have assigned the following annotations to the gene product of Hamp. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 7, 2014. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text for additional MGI annotations
  1. Chiga M et al. (2008) Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int, 74:1403-9. (PubMed:18800028)
  2. De Domenico I et al. (2010) Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest, 120:2395-405. (PubMed:20530874)
  3. Deschemin JC et al. (2013) Role of hepcidin in the setting of hypoferremia during acute inflammation. PLoS One, 8:e61050. (PubMed:23637785)
  4. Gardenghi S et al. (2014) Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus. Blood, 123:1137-45. (PubMed:24357729)
  5. Hadziahmetovic M et al. (2011) Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci, 52:109-18. (PubMed:20811044)
  6. Kim A et al. (2014) A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood, 123:1129-36. (PubMed:24357728)
  7. Lesbordes-Brion JC et al. (2006) Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood, 108:1402-5. (PubMed:16574947)
  8. Li JJ et al. (2012) Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis. Arterioscler Thromb Vasc Biol, 32:1158-66. (PubMed:22383698)
  9. Mastrogiannaki M et al. (2012) Deletion of HIF-2alpha in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice. Blood, 119:587-90. (PubMed:22128145)
  10. Murphy AT et al. (2007) Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood, 110:1048-54. (PubMed:17435114)
  11. Nemeth E et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306:2090-3. (PubMed:15514116)
  12. Nicolas G et al. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A, 98:8780-5. (PubMed:11447267)
  13. Park CH et al. (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem, 276:7806-10. (PubMed:11113131)
  14. Pigeon C et al. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem, 276:7811-9. (PubMed:11113132)
  15. Sun L et al. (2014) Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload. Gene, 543:161-5. (PubMed:24561287)
  16. Tselepis C et al. (2010) Characterization of the transition-metal-binding properties of hepcidin. Biochem J, 427:289-96. (PubMed:20113314)
  17. Venta PJ et al. (1985) Structure and exon to protein domain relationships of the mouse carbonic anhydrase II gene. J Biol Chem, 260:12130-5. (PubMed:2995362)
  18. Yuki KE et al. (2013) Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. PLoS One, 8:e55331. (PubMed:23390527)
  19. Zhang DL et al. (2011) Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts. Blood, 118:2868-77. (PubMed:21700773)
  20. Zumerle S et al. (2014) Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype. Blood, 123:3646-50. (PubMed:24646470)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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