GO Annotations Graph

• Symbol: Hamp
• Name: hepcidin antimicrobial peptide
• ID: MGI:1933533

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005507	copper ion binding	IDA	J:163060
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Molecular Function	GO:0097690	iron ion transmembrane transporter inhibitor activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0045179	apical cortex	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IDA	J:70464
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:208699
Cellular Component	GO:0005615	extracellular space	IDA	J:145397
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:67983
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0031668	cellular response to extracellular stimulus	TAS	J:222266
Biological Process	GO:0042742	defense response to bacterium	IDA	J:68030
Biological Process	GO:0042742	defense response to bacterium	IMP	J:199427
Biological Process	GO:0050832	defense response to fungus	ISO	J:164563
Biological Process	GO:0050832	defense response to fungus	IDA	J:8030
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:176914
Biological Process	GO:0006954	inflammatory response	IGI	J:163717
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:155856
Biological Process	GO:0006879	intracellular iron ion homeostasis	IDA	J:70464
Biological Process	GO:0034755	iron ion transmembrane transport	IGI	J:176914
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0042116	macrophage activation	IMP	J:196933
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	ISO	J:164563
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:200562
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:211683
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:208699
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IDA	J:163060
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:212430
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:119004
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:181769
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:163717
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:171564
Biological Process	GO:0002262	myeloid cell homeostasis	IMP	J:208698
Biological Process	GO:0045779	negative regulation of bone resorption	IMP	J:212430
Biological Process	GO:0050728	negative regulation of inflammatory response	IGI	J:163717
Biological Process	GO:1904479	negative regulation of intestinal absorption	ISO	J:164563
Biological Process	GO:0032413	negative regulation of ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:1904039	negative regulation of iron export across plasma membrane	ISO	J:164563
Biological Process	GO:0034760	negative regulation of iron ion transmembrane transport	IGI	J:176914
Biological Process	GO:1904255	negative regulation of iron ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:139214
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0043032	positive regulation of macrophage activation	IMP	J:196933
Biological Process	GO:0045732	positive regulation of protein catabolic process	IDA	J:176914
Biological Process	GO:1902916	positive regulation of protein polyubiquitination	ISO	J:164563
Biological Process	GO:2000646	positive regulation of receptor catabolic process	ISO	J:164563
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162717
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162717
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162717
Biological Process	GO:0030163	protein catabolic process	IDA	J:176914
Biological Process	GO:0030163	protein catabolic process	IDA	J:176914
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IDA	J:163717
Biological Process	GO:0010039	response to iron ion	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:162717
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:162717
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:162717