Automated description from the Alliance of Genome Resources
Exhibits enzyme binding activity. Contributes to transcription coactivator activity. Involved in several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Localizes to the RNA polymerase II transcription factor complex and mitochondrion. Predicted to colocalize with the microvillus and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; early infantile epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase).