Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits enzyme binding activity. Contributes to transcription coactivator activity. Involved in several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Localizes to RNA polymerase II transcription regulator complex; mitochondrion; and nucleus. Predicted to colocalize with microvillus and plasma membrane. Is expressed in several structures, including central nervous system; head mesenchyme derived from neural crest; musculoskeletal system; sensory organ; and spinal ganglion. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; early infantile epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase).
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