Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables frizzled binding activity and smoothened binding activity. Involved in embryonic morphogenesis; labyrinthine layer blood vessel development; and maternal placenta development. Acts upstream of or within several processes, including chordate embryonic development; regulation of gene expression; and regulation of signal transduction. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment. Is active in Golgi apparatus. Is expressed in several structures, including early conceptus; embryo ectoderm; placenta; sensory organ; and trunk mesenchyme. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2).