Automated description from the Alliance of Genome Resources
Exhibits serine-type peptidase activity. Involved in several processes, including chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Localizes to the collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1).