Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trps1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Trps1 has been shown to bind to the gene products of Ctbp2, Gli3, Rnf4. ^{[1, 2, 3]} Researchers have inferred, based on physical interactions, that the gene product of Trps1
  • participates in the following biological processes:
    • negative regulation of transcription, DNA-dependent ^[2]
  • performs the following molecular functions:
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Trps1
  • participates in the following biological processes:
    • regulation of chondrocyte differentiation ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Trps1:
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Trps1 encodes a protein or proteins that contain the following InterPro domains: Zinc finger, C2H2, Zinc finger, C2H2-like, Zinc finger, GATA-type, Zinc finger, NHR/GATA-type, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
    • zinc ion binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Trps1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding

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References

1. Kaiser FJ et al. (2003) The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. J Biol Chem, 278:38780-5. (PubMed:12885770)
2. Perdomo J et al. (2002) The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. Eur J Biochem, 269:5885-92. (PubMed:12444977)
3. Wuelling M et al. (2009) Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol, 328:40-53. (PubMed:19389374)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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