Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits C2H2 zinc finger domain binding activity; histone methyltransferase activity (H3-K27 specific); and histone methyltransferase activity (H3-K9 specific). Involved in several processes, including macromolecule methylation; negative regulation of transcription by RNA polymerase II; and positive regulation of cold-induced thermogenesis. Localizes to nucleus. Is expressed in several structures, including alimentary system; forelimb; integumental system; nervous system; and respiratory system. Used to study Kleefstra syndrome 1. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1).