Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; and neural plate anterior/posterior regionalization. Acts upstream of or within several processes, including anterior/posterior pattern specification; embryonic morphogenesis; and positive regulation of cell population proliferation. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including body cavity or lining; cardiovascular system; embryo mesenchyme; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in CAKUT2. Orthologous to human TBX18 (T-box transcription factor 18).