Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Acts upstream of or within labyrinthine layer blood vessel development and spongiotrophoblast layer development. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including heart; liver; lung; placenta; and spleen. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8).