Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable SMAD binding activity; signaling receptor binding activity; and ubiquitin protein ligase activity. Involved in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization. Acts upstream of or within negative regulation of ossification and protein ubiquitination. Predicted to be located in axon and neuronal cell body. Predicted to be active in cytoplasm and plasma membrane. Predicted to colocalize with mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1).