Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables histone demethylase activity (H3-K4 specific). Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; mammary gland duct morphogenesis; and positive regulation of mammary gland epithelial cell proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability; breast cancer; and high grade glioma. Orthologous to human KDM5B (lysine demethylase 5B).