Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits histone demethylase activity (H3-K4 specific). Involved in several processes, including cellular response to leukemia inhibitory factor; mammary gland duct morphogenesis; and regulation of gene expression. Predicted to localize to cytosol and histone methyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability; breast cancer; and malignant glioma. Orthologous to human KDM5B (lysine demethylase 5B).