Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grip1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Grip1
  • is located in the following cellular components:
    • dendrite ^[2]
    • membrane raft ^[1]
    • neuron projection ^[6]
    • plasma membrane ^[6]
• The gene product of Grip1 has been shown to bind to the gene products of Atad1, Ephb2, Lrrfip1. ^{[3, 5, 7, 8]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Grip1
  • participates in the following biological processes:
    • protein localization ^[4]
  • is located in the following cellular components:
    • recycling endosome ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Grip1:
  • participates in the following biological processes:
    • nervous system development
    • protein transport
  • performs the following molecular functions:
    • protein C-terminus binding
  • is located in the following cellular components:
    • neuronal cell body

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Grip1 indicates that it:
  • is located in the following cellular components:
    • cell junction
    • cytoplasmic vesicle
    • endoplasmic reticulum
    • membrane
    • postsynaptic membrane
    • synapse

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References

1. Bruckner K et al. (1999) EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron, 22:511-24. (PubMed:10197531)
2. Kaplan OI et al. (2012) Endocytosis Genes Facilitate Protein and Membrane Transport in C. elegans Sensory Cilia. Curr Biol, 22:451-60. (PubMed:22342749)
3. Lee YH et al. (2006) Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription. Nucleic Acids Res, 34:5052-9. (PubMed:16990252)
4. Takamiya K et al. (2004) A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet, 36:172-7. (PubMed:14730302)
5. Torres R et al. (1998) PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands [see comments] Neuron, 21:1453-63. (PubMed:9883737)
6. Uemura T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol Cell Neurosci, 26:330-41. (PubMed:15207857)
7. Zhang J et al. (2011) The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell, 145:284-99. (PubMed:21496646)
8. Zurner M et al. (2009) The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing. Genomics, 93:243-53. (PubMed:19013515)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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