Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including norepinephrine metabolic process; positive regulation of protein metabolic process; and serotonin metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal medulla; central nervous system; genitourinary system; lens; and thymus. Orthologous to human RNF180 (ring finger protein 180).