Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin ligase-substrate adaptor activity. Involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation involved in prostate gland development; regulation of transcription by RNA polymerase II; and secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development. Part of Cul4B-RING E3 ubiquitin ligase complex. Is expressed in genitourinary system. Orthologous to human WDR77 (WD repeat domain 77).