Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Chn1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Chn1
  • participates in the following biological processes:
    • regulation of axonogenesis ^[2]
    • regulation of Rac GTPase activity ^[2]
• The gene product of Chn1 has been shown to bind to the gene products of Epha4. ^{[1, 2]} Researchers have inferred, based on physical interactions, that the gene product of Chn1
  • performs the following molecular functions:
    • ephrin receptor binding ^{[1, 2]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Chn1
  • participates in the following biological processes:
    • ephrin receptor signaling pathway ^[1]
    • motor neuron axon guidance ^[1]
    • regulation of axonogenesis ^[1]

---

Summary text based on GO annotations supported by structural data

• Chn1 encodes a protein or proteins that contain the following InterPro domains: Diacylglycerol/phorbol-ester binding, N-chimaerin, Protein kinase C-like, phorbol ester/diacylglycerol binding, Rho GTPase activation protein, Rho GTPase-activating protein domain, SH2 domain, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction
    • signal transduction
  • is located in the following cellular components:
    • intracellular

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Chn1 indicates that it:
  • participates in the following biological processes:
    • nervous system development
  • performs the following molecular functions:
    • GTPase activator activity
    • metal ion binding

---

References

1. Beg AA et al. (2007) alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron, 55:768-78. (PubMed:17785183)
2. Iwasato T et al. (2007) Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell, 130:742-53. (PubMed:17719550)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---