Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rab39b. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rab39b
  • is located in the following cellular components:
    • Golgi apparatus ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rab39b
  • participates in the following biological processes:
    • synapse organization ^[1]
    • vesicle-mediated transport ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rab39b:
  • is located in the following cellular components:
    • Golgi apparatus
    • intracellular

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Summary text based on GO annotations supported by structural data

• Rab39b encodes a protein or proteins that contain the following InterPro domains: Small GTP-binding protein domain, Small GTPase superfamily, Small GTPase superfamily, Rab type, indicating that the gene product:
  • participates in the following biological processes:
    • protein transport
    • small GTPase mediated signal transduction
  • performs the following molecular functions:
    • GTP binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rab39b indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport
  • performs the following molecular functions:
    • GTP binding
    • nucleotide binding
  • is located in the following cellular components:
    • membrane
    • plasma membrane

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References

1. Giannandrea M et al. (2010) Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly. Am J Hum Genet, 86:185-95. (PubMed:20159109)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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