Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein ligase activity. Involved in negative regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including heart valve; respiratory system; sensory organ; skeleton; and tarsus. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein ligase 2).