Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of with a positive effect on regulation of autophagosome assembly. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver and biliary system; and musculoskeletal system. Orthologous to human RNF186 (ring finger protein 186).