Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnmb4. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on genetic interactions, that the gene product of Kcnmb4
  • performs the following molecular functions:
    • calcium-activated potassium channel activity based on interactions with Kcnma1 ^[1]
  • is located in the following cellular components:
    • voltage-gated potassium channel complex based on interactions with Kcnma1 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcnmb4:
  • participates in the following biological processes:
    • detection of calcium ion
    • potassium ion transport
    • regulation of action potential
    • regulation of action potential in neuron
  • performs the following molecular functions:
    • calcium-activated potassium channel activity
    • potassium channel activity
  • is located in the following cellular components:
    • integral to plasma membrane
    • voltage-gated potassium channel complex

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Summary text based on GO annotations supported by structural data

• Kcnmb4 encodes a protein or proteins that contain the following InterPro domains: Potassium channel, calcium-activated, BK, beta subunit, indicating that the gene product:
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnmb4 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Nehrke K et al. (2003) Molecular identification of Ca2+-activated K+ channels in parotid acinar cells. Am J Physiol Cell Physiol, 284:C535-46. (PubMed:12388098)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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