Gene Ontology Classifications

Symbol
Name
ID

Trem2
triggering receptor expressed on myeloid cells 2
MGI:1913150

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Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in several processes, including regulation of cytokine production; regulation of signal transduction; and response to bacterium. Acts upstream of with a positive effect on social behavior. Acts upstream of or within with a positive effect on defense response to Gram-negative bacterium. Acts upstream of or within with a negative effect on pyroptosis. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; phagocytosis, engulfment; and regulation of gene expression. Located in plasma membrane. Is expressed in central nervous system; embryo mesenchyme; genitourinary system; and limb interdigital region. Used to study frontotemporal dementia. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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