Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Robo2. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Robo2
  • is located in the following cellular components:
    • axolemma ^[5]
• Researchers have inferred, based on physical interactions, that the gene product of Robo2
  • performs the following molecular functions:
    • protein heterodimerization activity ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Robo2
  • participates in the following biological processes:
    • axon guidance ^[4]
    • metanephros development ^[3]
    • olfactory bulb interneuron development ^[2]
    • retinal ganglion cell axon guidance ^[7]
    • ureteric bud development ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Robo2
  • participates in the following biological processes:
    • axon midline choice point recognition based on interactions with Robo1 ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Robo2:
  • participates in the following biological processes:
    • axon guidance
    • homophilic cell adhesion
    • negative regulation of negative chemotaxis
    • positive regulation of axonogenesis
    • ureteric bud development
  • performs the following molecular functions:
    • axon guidance receptor activity
    • identical protein binding
  • is located in the following cellular components:
    • cell surface

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Robo2 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • chemotaxis
    • multicellular organismal development
    • nervous system development
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Camurri L et al. (2005) Evidence for the existence of two Robo3 isoforms with divergent biochemical properties. Mol Cell Neurosci, 30:485-93. (PubMed:16226035)
2. Fouquet C et al. (2007) Robo1 and robo2 control the development of the lateral olfactory tract. J Neurosci, 27:3037-45. (PubMed:17360927)
3. Grieshammer U et al. (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell, 6:709-17. (PubMed:15130495)
4. Long H et al. (2004) Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron, 42:213-23. (PubMed:15091338)
5. Sabatier C et al. (2004) The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell, 117:157-69. (PubMed:15084255)
6. Tamada A et al. (2008) Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing. Neural Dev, 3:29. (PubMed:18986510)
7. Thompson H et al. (2009) Robo2 is required for Slit-mediated intraretinal axon guidance. Dev Biol, 335:418-26. (PubMed:19782674)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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