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Gene Ontology Classifications
Symbol
Name
ID
Robo2
roundabout homolog 2 (Drosophila)
MGI:1890110

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Robo2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Camurri L et al. (2005) Evidence for the existence of two Robo3 isoforms with divergent biochemical properties. Mol Cell Neurosci, 30:485-93. (PubMed:16226035)
  2. Fouquet C et al. (2007) Robo1 and robo2 control the development of the lateral olfactory tract. J Neurosci, 27:3037-45. (PubMed:17360927)
  3. Grieshammer U et al. (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell, 6:709-17. (PubMed:15130495)
  4. Long H et al. (2004) Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron, 42:213-23. (PubMed:15091338)
  5. Sabatier C et al. (2004) The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell, 117:157-69. (PubMed:15084255)
  6. Tamada A et al. (2008) Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing. Neural Dev, 3:29. (PubMed:18986510)
  7. Thompson H et al. (2009) Robo2 is required for Slit-mediated intraretinal axon guidance. Dev Biol, 335:418-26. (PubMed:19782674)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory