Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gabarap. (This text reflects annotations as of Tuesday, May 21, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gabarap
  • participates in the following biological processes:
    • microtubule cytoskeleton organization ^[5]
  • performs the following molecular functions:
    • microtubule binding ^[5]
  • is located in the following cellular components:
    • actin cytoskeleton ^[5]
    • Golgi apparatus ^[3]
    • lysosome ^[3]
    • microtubule associated complex ^[5]
    • plasma membrane ^[2]
    • smooth endoplasmic reticulum ^[3]
• The gene product of Gabarap has been shown to bind to the gene products of Atg7. ^{[1, 2, 4]}

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gabarap:
  • participates in the following biological processes:
    • extrinsic apoptotic signaling pathway via death domain receptors
    • protein transport
  • performs the following molecular functions:
    • beta-tubulin binding
    • GABA receptor binding
  • is located in the following cellular components:
    • autophagic vacuole
    • autophagic vacuole membrane
    • cell body
    • perinuclear region of cytoplasm

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gabarap indicates that it:
  • participates in the following biological processes:
    • autophagy
    • transport
  • is located in the following cellular components:
    • cytoplasm
    • cytoplasmic vesicle
    • cytoskeleton
    • membrane
    • microtubule

---

References

1. Itoh T et al. (2011) OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. J Cell Biol, 192:839-53. (PubMed:21383079)
2. Kneussel M et al. (2000) The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci U S A, 97:8594-9. (PubMed:10900017)
3. Okazaki N et al. (2000) Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. Brain Res Mol Brain Res, 85:1-12. (PubMed:11146101)
4. Tanida I et al. (2002) Murine Apg12p Has a Substrate Preference for Murine Apg7p over Three Apg8p Homologs. Biochem Biophys Res Commun, 292:256-62. (PubMed:11890701)
5. Wang H et al. (2000) Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction. J Neurochem, 75:644-55. (PubMed:10899939)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---