Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rgs14. (This text reflects annotations as of Wednesday, August 14, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rgs14
  • participates in the following biological processes:
    • long-term synaptic potentiation ^[3]
    • nucleocytoplasmic transport ^[1]
    • regulation of DNA-dependent transcription in response to stress ^[1]
  • performs the following molecular functions:
    • GTPase activator activity ^[6]
    • receptor signaling protein activity ^[6]
  • is located in the following cellular components:
    • centrosome ^{[1, 4]}
    • cytoplasm ^{[1, 4, 6]}
    • dendrite ^[3]
    • dendritic spine ^[3]
    • nuclear body ^[1]
    • nucleus ^{[1, 4]}
    • plasma membrane ^[6]
    • postsynaptic density ^[3]
    • spindle ^{[4, 5]}
• The gene product of Rgs14 has been shown to bind to the gene products of Rabgef1. ^[6] Researchers have inferred, based on physical interactions, that the gene product of Rgs14
  • performs the following molecular functions:
    • GTPase activating protein binding ^{[2, 6]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rgs14
  • participates in the following biological processes:
    • chromosome segregation ^[4]
    • learning ^[3]
    • long-term memory ^[3]
    • mitosis ^[4]
    • negative regulation of MAP kinase activity ^[3]
    • negative regulation of synaptic plasticity ^[3]
    • spindle organization ^[4]
    • zygote asymmetric cell division ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rgs14:
  • participates in the following biological processes:
    • cell division
    • negative regulation of ERK1 and ERK2 cascade
    • nucleocytoplasmic transport
    • platelet-derived growth factor receptor signaling pathway
    • positive regulation of GTPase activity
    • positive regulation of neurogenesis
    • regulation of G-protein coupled receptor protein signaling pathway
    • response to oxidative stress
    • spindle organization
    • visual learning
  • performs the following molecular functions:
    • G-protein alpha-subunit binding
    • GDP-dissociation inhibitor activity
    • GTPase activator activity
    • microtubule binding
    • protein kinase binding
    • receptor signaling complex scaffold activity
  • is located in the following cellular components:
    • centrosome
    • cytoplasm
    • dendrite
    • intermediate filament cytoskeleton
    • nucleus
    • plasma membrane
    • spindle
    • spindle pole

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Summary text based on GO annotations supported by structural data

• Rgs14 encodes a protein or proteins that contain the following InterPro domains: GoLoco motif, Raf-like Ras-binding, Regulator of G protein signalling, Regulator of G protein signalling superfamily, Regulator of G-protein signaling, domain 1, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of catalytic activity
    • signal transduction
    • termination of G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • GTPase regulator activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rgs14 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • multicellular organismal development
    • negative regulation of signal transduction
  • is located in the following cellular components:
    • cell junction
    • cell projection
    • cytoskeleton
    • membrane
    • microtubule
    • postsynaptic membrane
    • synapse

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References

1. Cho H et al. (2005) RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock. J Biol Chem, 280:805-14. (PubMed:15520006)
2. Cho H et al. (2007) Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol, 178:245-55. (PubMed:17635935)
3. Lee SE et al. (2010) RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proc Natl Acad Sci U S A, 107:16994-8. (PubMed:20837545)
4. Martin-McCaffrey L et al. (2004) RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell, 7:763-9. (PubMed:15525537)
5. Martin-McCaffrey L et al. (2005) RGS14 is a microtubule-associated protein. Cell Cycle, 4:953-60. (PubMed:15917656)
6. Traver S et al. (2000) RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochem J, 350 Pt 1:19-29. (PubMed:10926822)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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