Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rgs14. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rgs14
  • participates in the following biological processes:
    • intracellular signal transduction ^[]
    • long-term synaptic potentiation ^[]
    • nucleocytoplasmic transport ^[]
    • regulation of DNA-templated transcription in response to stress ^[]
  • performs the following molecular functions:
    • GTPase activator activity ^[]
    • receptor signaling protein activity ^[]
  • is located in the following cellular components:
    • centrosome ^{[, ]}
    • cytoplasm ^{[, , ]}
    • dendrite ^[]
    • dendritic spine ^[]
    • nuclear body ^[]
    • nucleus ^{[, ]}
    • plasma membrane ^[]
    • postsynaptic density ^[]
    • spindle ^{[, ]}
• Researchers have inferred, based on physical interactions, that the gene product of Rgs14
  • performs the following molecular functions:
    • GTPase activating protein binding ^{[, ]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rgs14
  • participates in the following biological processes:
    • chromosome segregation ^[]
    • learning ^[]
    • long-term memory ^[]
    • mitotic nuclear division ^[]
    • negative regulation of MAP kinase activity ^[]
    • negative regulation of synaptic plasticity ^[]
    • spindle organization ^[]
    • zygote asymmetric cell division ^[]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rgs14:
  • participates in the following biological processes:
    • cell division
    • negative regulation of ERK1 and ERK2 cascade
    • nucleocytoplasmic transport
    • platelet-derived growth factor receptor signaling pathway
    • positive regulation of GTPase activity
    • positive regulation of neurogenesis
    • regulation of G-protein coupled receptor protein signaling pathway
    • response to oxidative stress
    • spindle organization
    • visual learning
  • performs the following molecular functions:
    • G-protein alpha-subunit binding
    • GDP-dissociation inhibitor activity
    • GTPase activator activity
    • microtubule binding
    • protein kinase binding
    • receptor signaling complex scaffold activity
  • is located in the following cellular components:
    • centrosome
    • cytoplasm
    • dendrite
    • nucleus
    • plasma membrane
    • spindle
    • spindle pole

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Summary text based on GO annotations supported by structural data

• Rgs14 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
    • termination of G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • GTPase regulator activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rgs14 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • multicellular organismal development
    • negative regulation of signal transduction
  • is located in the following cellular components:
    • cell junction
    • cell projection
    • cytoskeleton
    • membrane
    • microtubule
    • postsynaptic membrane
    • synapse

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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