Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including positive regulation of ubiquitin-dependent protein catabolic process; regulation of canonical NF-kappaB signal transduction; and vesicle-mediated transport to the plasma membrane. Predicted to act upstream of or within cholesterol homeostasis and regulation of plasma lipoprotein particle levels. Predicted to be located in centrosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22).