Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ppp1r3c. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ppp1r3c
  • participates in the following biological processes:
    • glycogen metabolic process ^[3]
• Researchers have inferred, based on physical interactions, that the gene product of Ppp1r3c
  • performs the following molecular functions:
    • protein phosphatase binding ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ppp1r3c
  • participates in the following biological processes:
    • glycogen biosynthetic process ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ppp1r3c:
  • participates in the following biological processes:
    • regulation of glycogen biosynthetic process
    • regulation of glycogen catabolic process
  • performs the following molecular functions:
    • enzyme binding
    • phosphoprotein phosphatase activity
  • is located in the following cellular components:
    • glycogen granule
    • intracellular membrane-bounded organelle

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ppp1r3c indicates that it:
  • participates in the following biological processes:
    • carbohydrate metabolic process

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References

1. Luo X et al. (2011) Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis. Diabetes, 60:1435-45. (PubMed:21471512)
2. O'Doherty RM et al. (2000) Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. J Clin Invest, 105:479-88. (PubMed:10683377)
3. Printen JA et al. (1997) PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science, 275:1475-8. (PubMed:9045612)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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