Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits ubiquitin protein ligase activity. Involved in several processes, including catecholamine metabolic process; chemical synaptic transmission; and negative regulation of intrinsic apoptotic signaling pathway. Localizes to several cellular components, including mitochondrion; neuron projection; and nucleus. Predicted to colocalize with mitochondrion-derived vesicle. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase).