Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables thioredoxin-disulfide reductase (NADPH) activity. Acts upstream of or within cell population proliferation; cellular oxidant detoxification; and mesoderm formation. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; integumental system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human TXNRD1 (thioredoxin reductase 1).