Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables group III metabotropic glutamate receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway. Predicted to be located in neuronal cell body and presynaptic membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Is expressed in several structures, including eye; gonad; ileum; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8).