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Gene Ontology Classifications
forkhead box J1

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GO curators for mouse genes have assigned the following annotations to the gene product of Foxj1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Alten L et al. (2012) Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development, 139:1276-84. (PubMed:22357932)
  2. Brody SL et al. (2000) Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am J Respir Cell Mol Biol, 23:45-51. (PubMed:10873152)
  3. Chen J et al. (1998) Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J Clin Invest, 102:1077-82. (PubMed:9739041)
  4. Danielian PS et al. (2007) E2f4 is required for normal development of the airway epithelium. Dev Biol, 305:564-76. (PubMed:17383628)
  5. Gomperts BN et al. (2004) Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci, 117:1329-37. (PubMed:14996907)
  6. Huang T et al. (2003) Foxj1 is required for apical localization of ezrin in airway epithelial cells. J Cell Sci, 116:4935-45. (PubMed:14625387)
  7. Lim L et al. (1997) The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc Natl Acad Sci U S A, 94:3094-9. (PubMed:9096351)
  8. Lin L et al. (2005) Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6. J Immunol, 175:951-8. (PubMed:16002694)
  9. Lin L et al. (2004) Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1. Science, 303:1017-20. (PubMed:14963332)
  10. Miller LA et al. (2001) Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J Histochem Cytochem, 49:1593-604. (PubMed:11724907)
  11. Pan J et al. (2007) RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1. J Cell Sci, 120:1868-76. (PubMed:17488776)
  12. Park KS et al. (2006) Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol, 294:192-202. (PubMed:16574095)
  13. Srivatsan S et al. (2005) Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress. J Immunol, 175:7805-9. (PubMed:16339515)

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Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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