Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of lymphocyte activation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell maturation; determination of left/right symmetry; and establishment of apical/basal cell polarity. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; nose; and respiratory system. Used to study Kartagener syndrome; congenital heart disease; and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1).
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