Automated description from the Alliance of Genome Resources (Release 3.1)
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of lymphocyte activation; and regulation of macromolecule biosynthetic process. Localizes to nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; nose; and respiratory system. Used to study Kartagener syndrome and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1).