Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Foxg1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Foxg1
  • participates in the following biological processes:
    • neurogenesis ^[1]
  • is located in the following cellular components:
    • nucleus ^[8]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Foxg1
  • participates in the following biological processes:
    • axon midline choice point recognition ^[6]
    • cell morphogenesis involved in neuron differentiation ^[5]
    • central nervous system neuron development ^[7]
    • dorsal/ventral pattern formation ^{[4, 9]}
    • forebrain development ^{[2, 3, 9, 10]}
    • inner ear morphogenesis ^[5]
    • negative regulation of neuron differentiation ^{[2, 3, 10]}
    • positive regulation of cell cycle ^[4]
    • positive regulation of neuroblast proliferation ^[4]
    • regulation of mitotic cell cycle ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Foxg1
  • participates in the following biological processes:
    • inner ear morphogenesis based on interactions with Fgf10 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Foxg1:
  • participates in the following biological processes:
    • embryo development ending in birth or egg hatching
    • hindbrain development
    • negative regulation of transcription from RNA polymerase II promoter
    • negative regulation of transcription, DNA-dependent
    • nonmotile primary cilium assembly
    • nose development
    • positive regulation of transcription from RNA polymerase II promoter
    • regulation of sequence-specific DNA binding transcription factor activity
    • tissue development
  • performs the following molecular functions:
    • DNA binding, bending
    • double-stranded DNA binding
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
    • transcription factor binding
  • is located in the following cellular components:
    • transcription factor complex

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Summary text based on GO annotations supported by structural data

• Foxg1 encodes a protein or proteins that contain the following InterPro domains: Transcription factor, fork head, Transcription factor, fork head, conserved site, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Foxg1 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding

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References

1. Choi PS et al. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron, 57:41-55. (PubMed:18184563)
2. Hanashima C et al. (2004) Foxg1 suppresses early cortical cell fate. Science, 303:56-9. (PubMed:14704420)
3. Hanashima C et al. (2002) Brain factor-1 controls the proliferation and differentiation of neocortical progenitor cells through independent mechanisms. J Neurosci, 22:6526-36. (PubMed:12151532)
4. Martynoga B et al. (2005) Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis. Dev Biol, 283:113-27. (PubMed:15893304)
5. Pauley S et al. (2006) Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear. Dev Dyn, 235:2470-2482. (PubMed:16691564)
6. Pratt T et al. (2004) The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse. Development, 131:3773-84. (PubMed:15240555)
7. Shen Q et al. (2006) The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci, 9:743-51. (PubMed:16680166)
8. Shibata M et al. (2008) MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium. J Neurosci, 28:10415-21. (PubMed:18842901)
9. Vyas A et al. (2003) Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted. J Comp Neurol, 466:545-53. (PubMed:14566948)
10. Xuan S et al. (1995) Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron, 14:1141-52. (PubMed:7605629)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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