Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables cyclin binding activity and identical protein binding activity. Involved in several processes, including embryonic cleavage; integrin-mediated signaling pathway; and regulation protein catabolic process at postsynapse. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus; nucleus; and postsynapse. Is active in glutamatergic synapse. Is expressed in several structures, including cerebral cortex; extraembryonic component; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3).