GO Annotations Graph

• Symbol: Cul3
• Name: cullin 3
• ID: MGI:1347360

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030332	cyclin binding	IPI	J:57761
Molecular Function	GO:0042802	identical protein binding	IPI	J:198882
Molecular Function	GO:0005112	Notch binding	ISO	J:225134
Molecular Function	GO:0031208	POZ domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:217619
Molecular Function	GO:0005515	protein binding	IPI	J:209066
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:214293
Molecular Function	GO:0005515	protein binding	IPI	J:198882
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005929	cilium	IEA	J:60000
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	IBA	J:265628
Cellular Component	GO:0031461	cullin-RING ubiquitin ligase complex	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:214293
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:117680
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:117680
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:117680
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:117680
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:117680
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:117680
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:57761
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0031514	motile cilium	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:57761
Cellular Component	GO:0005634	nucleus	IDA	J:214293
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005827	polar microtubule	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	IDA	J:117680
Cellular Component	GO:0036126	sperm flagellum	ISO	J:164563
Cellular Component	GO:0000922	spindle pole	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:117680
Biological Process	GO:0031145	anaphase-promoting complex-dependent catabolic process	ISS	J:57761
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0000902	cell morphogenesis	IMP	J:57761
Biological Process	GO:0030030	cell projection organization	IEA	J:60000
Biological Process	GO:0048208	COPII vesicle coating	ISO	J:164563
Biological Process	GO:0040016	embryonic cleavage	IMP	J:181630
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	ISO	J:164563
Biological Process	GO:0044346	fibroblast apoptotic process	IMP	J:122228
Biological Process	GO:0007369	gastrulation	IMP	J:57761
Biological Process	GO:0010467	gene expression	IMP	J:217619
Biological Process	GO:0001701	in utero embryonic development	IMP	J:57761
Biological Process	GO:0006954	inflammatory response	IMP	J:217619
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:181630
Biological Process	GO:0072576	liver morphogenesis	IMP	J:122228
Biological Process	GO:0000278	mitotic cell cycle	IMP	J:122228
Biological Process	GO:0007080	mitotic metaphase plate congression	ISO	J:164563
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:122228
Biological Process	GO:0032480	negative regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	ISO	J:164563
Biological Process	GO:0032467	positive regulation of cytokinesis	ISO	J:164563
Biological Process	GO:1901992	positive regulation of mitotic cell cycle phase transition	ISO	J:164563
Biological Process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IGI	J:165268
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	IMP	J:217619
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0006513	protein monoubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IDA	J:236520
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0016567	protein ubiquitination	IMP	J:217619
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:214293
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IMP	J:117680
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:117680
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IMP	J:117680
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:117680
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IEP	J:117680
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:117680
Biological Process	GO:0017145	stem cell division	IMP	J:181630
Biological Process	GO:0043149	stress fiber assembly	ISO	J:164563
Biological Process	GO:0001831	trophectodermal cellular morphogenesis	IMP	J:57761
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:225134
Biological Process	GO:0016192	vesicle-mediated transport	IEA	J:60000
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:142037