Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Map3k5. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Map3k5
  • participates in the following biological processes:
    • activation of MAPK activity ^[2]
    • positive regulation of apoptotic process ^[1]
  • performs the following molecular functions:
    • MAP kinase kinase kinase activity ^[1]
• The gene product of Map3k5 has been shown to bind to the gene products of Map2k3, Ywhaz. ^{[1, 3]} Researchers have inferred, based on physical interactions, that the gene product of Map3k5
  • performs the following molecular functions:
    • protein kinase binding ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Map3k5
  • participates in the following biological processes:
    • regulation of cell death based on interactions with Ywhaz ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Map3k5:
  • participates in the following biological processes:
    • activation of cysteine-type endopeptidase activity involved in apoptotic process
    • activation of MAPKK activity
    • cellular response to hydrogen peroxide
    • intrinsic apoptotic signaling pathway in response to oxidative stress
    • JNK cascade
    • MAPK cascade
    • positive regulation of apoptotic process
    • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • performs the following molecular functions:
    • ATP binding
    • cysteine-type endopeptidase activator activity involved in apoptotic process
    • identical protein binding
    • magnesium ion binding
    • MAP kinase kinase kinase activity
    • protein homodimerization activity
    • protein kinase activity
    • protein phosphatase binding

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Summary text based on GO annotations supported by structural data

• Map3k5 encodes a protein or proteins that contain the following InterPro domains: Domain of unknown function DUF4071, Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine- / dual specificity protein kinase, catalytic domain, Serine/threonine-protein kinase, active site, Sterile alpha motif/pointed domain, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
  • performs the following molecular functions:
    • protein serine/threonine kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Map3k5 indicates that it:
  • participates in the following biological processes:
    • apoptotic process
    • innate immune response
    • phosphorylation
    • response to stress
  • performs the following molecular functions:
    • kinase activity
    • metal ion binding
    • nucleotide binding
    • protein serine/threonine kinase activity
    • transferase activity
  • is located in the following cellular components:
    • cytoplasm
    • endoplasmic reticulum

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References

1. Jung H et al. (2008) Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. J Biol Chem, 283:34541-53. (PubMed:18948261)
2. Kelkar N et al. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol, 25:2733-43. (PubMed:15767678)
3. Zhou J et al. (2009) Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol, 29:4167-76. (PubMed:19451227)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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