Automated description from the Alliance of Genome Resources
Exhibits MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of MAPK cascade; and positive regulation of cell death. Predicted to localize to several cellular components, including the IRE1-TRAF2-ASK1 complex; external side of plasma membrane; and protein kinase complex. Human ortholog(s) of this gene implicated in Huntington's disease. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).