Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nr2e3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nr2e3
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent ^[1]
  • performs the following molecular functions:
    • sequence-specific DNA binding transcription factor activity ^[1]
  • is located in the following cellular components:
    • nucleus ^[1]
    • transcription factor complex ^[1]
• The gene product of Nr2e3 has been shown to bind to the gene products of Crx. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nr2e3
  • participates in the following biological processes:
    • eye photoreceptor cell development ^[2]
    • negative regulation of cell proliferation ^[3]
    • retina development in camera-type eye ^{[2, 3]}
• Researchers have inferred, based on genetic interactions, that the gene product of Nr2e3
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter based on interactions with Crx ^[1]
    • positive regulation of rhodopsin gene expression based on interactions with Crx, Nrl ^[1]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Crx ^[1]

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Summary text based on GO annotations supported by structural data

• Nr2e3 encodes a protein or proteins that contain the following InterPro domains: Nuclear hormone receptor, ligand-binding, Nuclear hormone receptor, ligand-binding, core, Steroid hormone receptor, Transcription factor COUP, Zinc finger, NHR/GATA-type, Zinc finger, nuclear hormone receptor-type, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular receptor mediated signaling pathway
    • steroid hormone mediated signaling pathway
  • performs the following molecular functions:
    • DNA binding
    • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
    • sequence-specific DNA binding
    • steroid hormone receptor activity
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nr2e3 indicates that it:
  • participates in the following biological processes:
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding

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References

1. Peng GH et al. (2005) The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes. Hum Mol Genet, 14:747-64. (PubMed:15689355)
2. Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol, 2011:391384. (PubMed:21052544)
3. Yanagi Y et al. (2002) Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development. Invest Ophthalmol Vis Sci, 43:3489-94. (PubMed:12407160)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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