Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits beta-catenin binding activity. Involved in several processes, including animal organ development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; and regulation of transcription, DNA-templated. Localizes to cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling).