Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including BAT3 complex binding activity; ubiquitin-specific protease binding activity; and ubiquitin-ubiquitin ligase activity. Involved in negative regulation of canonical Wnt signaling pathway and regulation of SREBP signaling pathway. Predicted to be located in several cellular components, including growth cone; neuronal cell body; and perinuclear region of cytoplasm. Predicted to be part of Derlin-1 retrotranslocation complex and ubiquitin ligase complex. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; integumental system; liver; and retina nuclear layer. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 89. Orthologous to human AMFR (autocrine motility factor receptor).