Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Zeb1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 27, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Zeb1
  • participates in the following biological processes:
    • cellular response to amino acid stimulus ^[9]
    • negative regulation of transcription, DNA-dependent ^[10]
    • positive regulation of neuron differentiation ^[10]
    • positive regulation of transcription from RNA polymerase II promoter ^[8]
  • performs the following molecular functions:
    • chromatin binding ^[8]
    • E-box binding ^[10]
    • sequence-specific DNA binding transcription factor activity ^[12]
  • is located in the following cellular components:
    • nucleus ^{[1, 10]}
    • transcription factor complex ^[12]
• The gene product of Zeb1 has been shown to bind to the gene products of Srf. ^[8] Researchers have inferred, based on physical interactions, that the gene product of Zeb1
  • performs the following molecular functions:
    • transcription factor binding ^[12]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Zeb1
  • participates in the following biological processes:
    • cartilage development ^[11]
    • cochlea morphogenesis ^[4]
    • embryonic camera-type eye morphogenesis ^[5]
    • embryonic skeletal system morphogenesis ^[11]
    • negative regulation of cell proliferation ^[5]
    • negative regulation of epithelial cell differentiation ^[6]
    • negative regulation of transcription from RNA polymerase II promoter ^[12]
    • organ development ^[2]
    • pattern specification process ^[11]
    • regulation of mesenchymal cell proliferation ^[6]
    • regulation of smooth muscle cell differentiation ^[8]
    • regulation of T cell differentiation in thymus ^{[3, 11]}
    • semicircular canal morphogenesis ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Zeb1
  • participates in the following biological processes:
    • central nervous system development based on interactions with Zeb2 ^[7]
    • embryonic morphogenesis based on interactions with Zeb2 ^[7]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Smad3, Smad4, Srf ^[8]
    • regulation of transforming growth factor beta receptor signaling pathway based on interactions with Smad3 ^[8]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Zeb1:
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter
    • negative regulation of transcription, DNA-dependent
    • positive regulation of transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • chromatin binding
    • double-stranded DNA binding
    • sequence-specific DNA binding
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Zeb1 encodes a protein or proteins that contain the following InterPro domains: Homeodomain, Homeodomain-like, Zinc finger C2H2-type/integrase DNA-binding domain, Zinc finger, C2H2, Zinc finger, C2H2-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • nucleic acid binding
    • zinc ion binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Zeb1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • nervous system development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding

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References

1. Darling DS et al. (2003) Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons. Gene Expr Patterns, 3:709-17. (PubMed:14643678)
2. Gong SG et al. (2001) Palatal development in Twirler mice. Cleft Palate Craniofac J, 38:622-8. (PubMed:11681996)
3. Higashi Y et al. (1997) Impairment of T cell development in deltaEF1 mutant mice. J Exp Med, 185:1467-79. (PubMed:9126927)
4. Kurima K et al. (2011) A noncoding point mutation of zeb1 causes multiple developmental malformations and obesity in twirler mice. PLoS Genet, 7:e1002307. (PubMed:21980308)
5. Liu Y et al. (2008) Zeb1 mutant mice as a model of posterior corneal dystrophy. Invest Ophthalmol Vis Sci, 49:1843-9. (PubMed:18436818)
6. Liu Y et al. (2008) Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development, 135:579-88. (PubMed:18192284)
7. Miyoshi T et al. (2006) Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev Dyn, 235:1941-1952. (PubMed:16598713)
8. Nishimura G et al. (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell, 11:93-104. (PubMed:16824956)
9. Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest, 90:1437-46. (PubMed:20548288)
10. Ravanpay AC et al. (2010) Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation. Mol Cell Neurosci, 44:178-89. (PubMed:20346398)
11. Takagi T et al. (1998) DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development, 125:21-31. (PubMed:9389660)
12. Wang J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature, 446:882-7. (PubMed:17392792)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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