About   Help   FAQ
Gene Ontology Classifications
zinc finger E-box binding homeobox 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Zeb1. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 27, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Darling DS et al. (2003) Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons. Gene Expr Patterns, 3:709-17. (PubMed:14643678)
  2. Gong SG et al. (2001) Palatal development in Twirler mice. Cleft Palate Craniofac J, 38:622-8. (PubMed:11681996)
  3. Higashi Y et al. (1997) Impairment of T cell development in deltaEF1 mutant mice. J Exp Med, 185:1467-79. (PubMed:9126927)
  4. Kurima K et al. (2011) A noncoding point mutation of zeb1 causes multiple developmental malformations and obesity in twirler mice. PLoS Genet, 7:e1002307. (PubMed:21980308)
  5. Lee B et al. (2014) Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell, 29:47-58. (PubMed:24735878)
  6. Liu Y et al. (2008) Zeb1 mutant mice as a model of posterior corneal dystrophy. Invest Ophthalmol Vis Sci, 49:1843-9. (PubMed:18436818)
  7. Liu Y et al. (2008) Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development, 135:579-88. (PubMed:18192284)
  8. Miyoshi T et al. (2006) Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev Dyn, 235:1941-1952. (PubMed:16598713)
  9. Nishimura G et al. (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell, 11:93-104. (PubMed:16824956)
  10. Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest, 90:1437-46. (PubMed:20548288)
  11. Ravanpay AC et al. (2010) Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation. Mol Cell Neurosci, 44:178-89. (PubMed:20346398)
  12. Shirakihara T et al. (2011) TGF-beta regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J, 30:783-95. (PubMed:21224849)
  13. Takagi T et al. (1998) DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development, 125:21-31. (PubMed:9389660)
  14. Wang J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature, 446:882-7. (PubMed:17392792)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory