Automated description from the Alliance of Genome Resources
Exhibits chromatin binding activity and damaged DNA binding activity. Contributes to guanine/thymine mispair binding activity. Involved in several processes, including DNA metabolic process; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic hypermutation of immunoglobulin genes. Localizes to the MutSalpha complex and nuclear chromatin. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 5. Orthologous to human MSH6 (mutS homolog 6).