Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits chromatin binding activity and damaged DNA binding activity. Contributes to guanine/thymine mispair binding activity. Involved in several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic diversification of immunoglobulins. Localizes to MutSalpha complex and nuclear chromatin. Is expressed in several structures, including brain; early conceptus; liver; lung; and oocyte. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 5. Orthologous to human MSH6 (mutS homolog 6).