Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits thyroxine 5'-deiodinase activity. Involved in brown fat cell differentiation; positive regulation of cold-induced thermogenesis; and thyroid hormone catabolic process. Predicted to localize to integral component of membrane. Is expressed in several structures, including alimentary system; brown fat; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2).