Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables thyroxine 5'-deiodinase activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within brown fat cell differentiation; cellular lipid metabolic process; and thyroid hormone catabolic process. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brown fat; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2).