Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ikbkg. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ikbkg
  • participates in the following biological processes:
    • activation of NF-kappaB-inducing kinase activity ^[3]
  • is located in the following cellular components:
    • cytoplasm ^[3]
• The gene product of Ikbkg has been shown to bind to the gene products of Chuk, Eaf2, Ikbkb, Terf2ip. ^{[1, 2, 4, 6, 7]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ikbkg
  • participates in the following biological processes:
    • B cell homeostasis ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ikbkg:
  • participates in the following biological processes:
    • positive regulation of NF-kappaB transcription factor activity
    • response to DNA damage stimulus
  • performs the following molecular functions:
    • protein domain specific binding
    • protein heterodimerization activity
  • is located in the following cellular components:
    • cytoplasm
    • cytoplasmic part
    • cytosol
    • IkappaB kinase complex
    • intracellular
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ikbkg indicates that it:
  • participates in the following biological processes:
    • phosphorylation
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • kinase activity
    • metal ion binding

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References

1. Chen RA et al. (2008) Inhibition of IkappaB kinase by vaccinia virus virulence factor B14. PLoS Pathog, 4:e22. (PubMed:18266467)
2. Cui J et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell, 141:483-96. (PubMed:20434986)
3. Iha H et al. (2003) Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling. Oncogene, 22:8912-23. (PubMed:14654787)
4. Neely RJ et al. (2011) The RET/PTC3 oncogene activates classical NF-kappaB by stabilizing NIK. Oncogene, 30:87-96. (PubMed:20818435)
5. Pasparakis M et al. (2002) IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med, 196:743-52. (PubMed:12235208)
6. Saso K et al. (2003) Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. J Biochem, 133:493-500. (PubMed:12761297)
7. Teo H et al. (2010) Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol, 12:758-67. (PubMed:20622870)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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