Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables chromatin binding activity; sequence-specific double-stranded DNA binding activity; and transcription corepressor activity. Involved in establishment of skin barrier; gene expression; and protein stabilization. Acts upstream of or within several processes, including forebrain development; positive regulation of protein deacetylation; and type I pneumocyte differentiation. Located in nuclear body. Part of histone deacetylase complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; retina layer; and tooth. Used to study myelofibrosis. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR2 (nuclear receptor corepressor 2).