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Gene Ontology Classifications
nuclear receptor co-repressor 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Ncor2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 21, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Fuhrmann G et al. (2001) Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell, 1:377-87. (PubMed:11702949)
  2. Ghisletti S et al. (2009) Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev, 23:681-93. (PubMed:19299558)
  3. Gregoire S et al. (2007) Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol, 27:1280-95. (PubMed:17158926)
  4. Guan HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev, 19:453-61. (PubMed:15681609)
  5. Hartman HB et al. (2005) The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. EMBO Rep, 6:445-51. (PubMed:15832170)
  6. Jacobs FM et al. (2009) Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development, 136:531-40. (PubMed:19144721)
  7. Jepsen K et al. (2008) Cooperative regulation in development by SMRT and FOXP1. Genes Dev, 22:740-5. (PubMed:18347093)
  8. Jepsen K et al. (2007) SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature, 450:415-9. (PubMed:17928865)
  9. Kao HY et al. (2000) Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev, 14:55-66. (PubMed:10640276)
  10. Ki SH et al. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol Cell Biol, 25:4150-65. (PubMed:15870285)
  11. Kim MY et al. (2006) A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci U S A, 103:13074-9. (PubMed:16924111)
  12. Lyst MJ et al. (2013) Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nat Neurosci, 16:898-902. (PubMed:23770565)
  13. Nofsinger RR et al. (2008) SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A, 105:20021-6. (PubMed:19066220)
  14. Ordentlich P et al. (1999) Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A, 96:2639-44. (PubMed:10077563)
  15. Pei L et al. (2011) Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med, 17:1466-72. (PubMed:22001906)
  16. Potter GB et al. (2001) The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev, 15:2687-701. (PubMed:11641275)
  17. Yang X et al. (2005) Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. J Biol Chem, 280:18710-6. (PubMed:15778499)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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