Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits 1-phosphatidylinositol-4-phosphate 5-kinase activity and zinc ion binding activity. Involved in intracellular signal transduction and myelin assembly. Localizes to several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing).