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Gene Ontology Classifications
solute carrier family 40 (iron-regulated transporter), member 1

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GO curators for mouse genes have assigned the following annotations to the gene product of Slc40a1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. De Domenico I et al. (2010) Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest, 120:2395-405. (PubMed:20530874)
  2. De Domenico I et al. (2011) The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin. Cell Metab, 14:635-46. (PubMed:22019085)
  3. Delaby C et al. (2005) Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood, 106:3979-84. (PubMed:16081696)
  4. Duce JA et al. (2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell, 142:857-67. (PubMed:20817278)
  5. Haile DJ. (2000) Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization. Cytogenet Cell Genet, 88:328-9. (PubMed:10828623)
  6. Iacovelli J et al. (2009) Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Brain Res, 1289:85-95. (PubMed:19596281)
  7. Mok H et al. (2004) Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice. Development, 131:4871-81. (PubMed:15342464)
  8. Nemeth E et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306:2090-3. (PubMed:15514116)
  9. Vernay B et al. (2005) Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci, 25:4856-67. (PubMed:15888661)
  10. White C et al. (2013) HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab, 17:261-70. (PubMed:23395172)
  11. Wu LJ et al. (2004) Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res, 1001:108-17. (PubMed:14972659)
  12. Zhang DL et al. (2011) Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts. Blood, 118:2868-77. (PubMed:21700773)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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