Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc40a1. (This text reflects annotations as of Tuesday, July 8, 2014.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc40a1
  • participates in the following biological processes:
    • iron ion transmembrane transport ^[]
    • iron ion transport ^[]
    • regulation of transcription from RNA polymerase II promoter in response to iron ^[]
  • performs the following molecular functions:
    • iron ion transmembrane transporter activity ^[]
  • is located in the following cellular components:
    • multivesicular body ^[]
    • plasma membrane ^[]
    • synaptic vesicle ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc40a1
  • participates in the following biological processes:
    • endothelium development ^[]
    • lymphocyte homeostasis ^[]
    • multicellular organismal iron ion homeostasis ^[]
    • negative regulation of apoptotic process ^[]
    • spleen development ^[]
    • spleen trabecula formation ^[]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc40a1:
  • participates in the following biological processes:
    • cellular iron ion homeostasis
    • iron ion transmembrane transport
  • performs the following molecular functions:
    • iron ion transmembrane transporter activity
  • is located in the following cellular components:
    • basolateral plasma membrane
    • intracellular
    • plasma membrane

---

Summary text based on GO annotations supported by structural data

• Slc40a1 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • is located in the following cellular components:
    • integral component of membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc40a1 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • iron ion homeostasis
    • transport
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

---

References

1. . () , :. (PubMed:)
2. . () , :. (PubMed:)
3. . () , :. (PubMed:)
4. . () , :. (PubMed:)
5. . () , :. (PubMed:)
6. . () , :. (PubMed:)
7. . () , :. (PubMed:)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---