Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc40a1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc40a1
  • participates in the following biological processes:
    • iron ion transmembrane transport ^[3]
    • iron ion transport ^[3]
    • regulation of transcription from RNA polymerase II promoter in response to iron ^[6]
  • performs the following molecular functions:
    • iron ion transmembrane transporter activity ^[3]
  • is located in the following cellular components:
    • multivesicular body ^[1]
    • plasma membrane ^[1]
    • synaptic vesicle ^[7]
• The gene product of Slc40a1 has been shown to bind to the gene products of App. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc40a1
  • participates in the following biological processes:
    • endothelium development ^[4]
    • lymphocyte homeostasis ^[5]
    • multicellular organismal iron ion homeostasis ^[4]
    • negative regulation of apoptotic process ^[4]
    • spleen development ^[4]
    • spleen trabecula formation ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc40a1:
  • participates in the following biological processes:
    • cellular iron ion homeostasis
    • iron ion transmembrane transport
  • performs the following molecular functions:
    • iron ion transmembrane transporter activity
  • is located in the following cellular components:
    • basolateral plasma membrane
    • intracellular
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Slc40a1 encodes a protein or proteins that contain the following InterPro domains: Ferroporti-1, Major facilitator superfamily domain, general substrate transporter, indicating that the gene product:
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc40a1 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • iron ion homeostasis
    • transport
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. De Domenico I et al. (2011) The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin. Cell Metab, 14:635-46. (PubMed:22019085)
2. Duce JA et al. (2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell, 142:857-67. (PubMed:20817278)
3. Haile DJ. (2000) Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization. Cytogenet Cell Genet, 88:328-9. (PubMed:10828623)
4. Mok H et al. (2004) Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice. Development, 131:4871-81. (PubMed:15342464)
5. Vernay B et al. (2005) Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci, 25:4856-67. (PubMed:15888661)
6. White C et al. (2013) HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab, 17:261-70. (PubMed:23395172)
7. Wu LJ et al. (2004) Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res, 1001:108-17. (PubMed:14972659)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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