Automated description from the Alliance of Genome Resources (Release 4.2.0)
Enables hexokinase activity. Involved in negative regulation of mitochondrial membrane permeability and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including carbohydrate phosphorylation; cellular response to leukemia inhibitory factor; and regulation of glucose import. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2).