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Gene Ontology Classifications
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Cited2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Bamforth SD et al. (2001) Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet, 29:469-74. (PubMed:11694877)
  2. Bamforth SD et al. (2004) Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet, 36:1189-96. (PubMed:15475956)
  3. Barbera JP et al. (2002) Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet, 11:283-93. (PubMed:11823447)
  4. Buaas FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet, 18:2989-3001. (PubMed:19457926)
  5. Chen Y et al. (2008) Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development, 135:2939-48. (PubMed:18653562)
  6. Chen Y et al. (2007) Cited2 is required for normal hematopoiesis in the murine fetal liver. Blood, 110:2889-98. (PubMed:17644732)
  7. Chou YT et al. (2006) Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene, 25:5547-60. (PubMed:16619037)
  8. Glenn DJ et al. (1999) MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J Biol Chem, 274:36159-67. (PubMed:10593900)
  9. Michell AC et al. (2010) A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2. Dev Dyn, 239:1988-94. (PubMed:20549734)
  10. Qu X et al. (2007) Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J, 26:4445-56. (PubMed:17932483)
  11. Rajan S et al. (2011) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol Genomics, null:null. (PubMed:22147266)
  12. Schneider JE et al. (2004) Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol, 4:16. (PubMed:15615595)
  13. Sun HB et al. (1998) MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity. Proc Natl Acad Sci U S A, 95:13555-60. (PubMed:9811838)
  14. Val P et al. (2007) Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development, 134:2349-58. (PubMed:17537799)
  15. Weninger WJ et al. (2005) Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development, 132:1337-48. (PubMed:15750185)
  16. Withington SL et al. (2006) Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. Dev Biol, 294:67-82. (PubMed:16579983)
  17. Yin Z et al. (2002) The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A, 99:10488-93. (PubMed:12149478)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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